The main goal of the DriverMap AIR assays is to:

  • Characterize the global AIR repertoire in normal and pathological conditions
  • Identify activated subsets of TCR and BCR clonotypes in the adaptive immune response
  • Identify disease- or pathogen-specific TCR and BCR clonotypes (both CDR3 (or CDR1-CDR2-CDR3) sequences and chain-pairing)
  • Characterize the phenotype of antigen-specific, activated T and B cells

Currently, most available AIR technologies are based on the amplification of TCR and BCR sequences followed by NGS but provide only partial immune receptor repertoire information [1-7,18] and are characterized by significant systematic biases [8, 14]. The following sections will provide practical guidelines for selecting the best design strategy for AIR experiments.

Last modified: 22 February 2023

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